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課程名稱 |
生物分析化學
Bio-analytical Chemistry |
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開課學期 |
111-1 |
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授課對象 |
理學院 化學所化學組 |
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授課教師 |
陳玉如 |
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課號 |
Chem5056 |
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課程識別碼 |
223 U2630 |
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班次 |
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學分 |
3.0 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期二6,7,8(13:20~16:20) |
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上課地點 |
化210室 |
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備註 |
本課程中文授課,使用英文教科書。
限學士班三年級以上 且 限本系所學生(含輔系、雙修生)
總人數上限：80人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
內容: 現代生物分析技術及在生物化學、臨床醫學的應用。
Concepts and General Principles of Analytical Biochemistry
Centrifugation Methods in Biochemistry
Purification and Identification of Biomolecules by Chromatography
Characterization of Protein and Nucleic Acids by Electrophoresis
Mass Spectrometry in Biomedical Applications
Spectroscopic Analysis of Biomolecules: FRET, X-ray Crystallography, MRI
Biomolecular Interaction Biosensor
Computer in Biochemistry and Molecular Biology
Real World Problems: SNP analysis, Cancer Diagnosis |
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課程目標 |
a |
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課程要求 |
a |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
1. Principle and Techniques of Biochemistry and Molecular Biology
(6th edition, 2005, CAMBRIDGE), by Keith Wilson and John Walker
2. Analytical Biochemistry (3rd edition, 1998, LONGMAN), by David J. Holmes
and Hazel Peck, |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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第1週 |
9/6 |
Introduction |
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第2週 |
9/13 |
Chapter 1: Basics and Statistics of Analytical Biochemistry |
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第3週 |
9/20 |
Chapter 2 Centrifugation Methods |
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第4週 |
9/27 |
Chapter 3 Separation and Purification Methods --Electrophoretic Techniques |
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第5週 |
10/4 |
Chapter 4 Separation by Chromatography |
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第6週 |
10/11 |
Chapter 5 Mass Spectrometry-based Protein Identification
(Part 1) |
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第7週 |
10/18 |
Chapter 5 Mass Spectrometry-based Protein Identification (Part 2) |
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第8週 |
10/25 |
Chapter 6 Quantitation methods for protein and proteomics |
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第9週 |
11/1 |
Chapter 6 3D Structure by X-ray Crystallography and Cryo-EM |
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第10週 |
11/8 |
期中考 |
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第11週 |
11/15 |
Chap 8 Visualization by Microscopy, TEM & SEM |
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第12週 |
11/22 |
Chap 10 Diagnosis of Single Nucleotide Polymorphisms |
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第13週 |
11/29 |
Chap 9 Principle and Application of NMR Spectroscopy |
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第14週 |
12/6 |
Chap 10 Principle and Application of NMR Spectroscopy |
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第15週 |
12/13 |
Special Topic: Precision Medicine |
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第16週 |
12/20 |
Cancer Diagnosis |
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第17週 |
12/27 |
期末考 |
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第18週 |
1/3 |
Final Report |
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